Rick G Schnellmann Selected Research

calpain 10

10/2012	Calpains, mitochondria, and apoptosis.
8/2012	Calpain 10 homology modeling with CYGAK and increased lipophilicity leads to greater potency and efficacy in cells.
7/2012	Loss of calpain 10 causes mitochondrial dysfunction during chronic hyperglycemia.
2/2012	Chronic high glucose downregulates mitochondrial calpain 10 and contributes to renal cell death and diabetes-induced renal injury.
1/2009	Identification and optimization of a novel inhibitor of mitochondrial calpain 10.
2/2008	Mitochondrial calpain 10 activity and expression in the kidney of multiple species.
12/2006	Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Rick G Schnellmann Research Topics

Disease

23	Ischemia 11/2022 - 03/2003
23	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 07/2002
22	Acute Kidney Injury (Acute Renal Failure) 11/2022 - 03/2003
13	Necrosis 08/2021 - 02/2007
11	Inflammation (Inflammations) 01/2017 - 02/2007
7	Reperfusion Injury 01/2019 - 02/2008
7	Fibrosis (Cirrhosis) 01/2016 - 10/2012
5	Spinal Cord Injuries (Spinal Cord Injury) 01/2021 - 12/2017
5	Contusions 01/2021 - 01/2019
5	Neoplasms (Cancer) 01/2017 - 07/2004
4	Diabetic Nephropathies (Diabetic Nephropathy) 11/2020 - 07/2012
4	Hypoxia (Hypoxemia) 02/2012 - 07/2002
3	Stroke (Strokes) 12/2022 - 12/2016
3	Type 2 Diabetes Mellitus (MODY) 11/2020 - 02/2012
3	Atrophy 12/2019 - 01/2014
3	Sepsis (Septicemia) 12/2017 - 02/2015
3	Trypanosomiasis 02/2016 - 02/2009
3	Hyperglycemia 08/2015 - 07/2012
3	Wounds and Injuries (Trauma) 05/2010 - 12/2006
2	Infarction (Infarctions) 12/2022 - 01/2022
2	Chronic Disease (Chronic Diseases) 03/2022 - 01/2016
2	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2016
2	Body Weight (Weight, Body) 01/2021 - 01/2013
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2020 - 01/2017
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2016 - 01/2016
2	Fatty Liver 01/2016 - 07/2012
2	Hypertrophy 08/2015 - 12/2014
2	Kidney Neoplasms (Kidney Cancer) 02/2007 - 01/2007
2	Carcinoma (Carcinomatosis) 10/2006 - 07/2004
1	Ischemic Stroke 12/2022
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 12/2022
1	Hepatitis 01/2022
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2022
1	Liver Diseases (Liver Disease) 01/2022
1	Alzheimer Disease (Alzheimer's Disease) 01/2022
1	Retinal Degeneration 07/2021

Drug/Important Bio-Agent (IBA)

11	Formoterol Fumarate (Oxis)FDA Link 11/2022 - 06/2014
7	Proteins (Proteins, Gene)FDA Link 12/2016 - 02/2008
7	calpain 10IBA 10/2012 - 12/2006
6	Adenosine Triphosphate (ATP)IBA 01/2018 - 03/2008
6	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 07/2002
6	Suramin (Suramin Sodium)IBA 02/2016 - 02/2009
5	Pharmaceutical PreparationsIBA 02/2016 - 03/2003
5	CalpainIBA 10/2012 - 07/2002
4	salicylhydroxamic acid (SHAM)IBA 01/2021 - 05/2015
4	CalciumIBA 01/2020 - 12/2006
4	Mitochondrial DNA (mtDNA)IBA 12/2019 - 08/2014
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 01/2007
4	Oxidants (Oxidizing Agents)IBA 08/2012 - 06/2005
3	CytokinesIBA 01/2022 - 01/2016
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 08/2021 - 01/2003
3	5-HT1F Serotonin ReceptorIBA 01/2021 - 01/2018
3	Glucose (Dextrose)FDA LinkGeneric 11/2020 - 02/2012
3	Oxygen (Dioxygen)IBA 01/2020 - 02/2008
3	LY 344864IBA 01/2020 - 08/2014
3	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2019 - 05/2015
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2016 - 06/2008
3	Alanine Transaminase (SGPT)IBA 02/2013 - 03/2008
3	Transcription Factors (Transcription Factor)IBA 01/2013 - 02/2008
3	Cysteine Proteases (Cysteine Protease)IBA 10/2012 - 07/2012
3	CaspasesIBA 10/2012 - 07/2004
3	Caspase 3 (Caspase-3)IBA 10/2012 - 07/2002
2	CreatinineIBA 11/2022 - 01/2014
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 09/2020 - 12/2014
2	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 08/2014
2	ceramide glucosyltransferaseIBA 01/2017 - 08/2015
2	ErbB Receptors (EGF Receptor)IBA 12/2016 - 06/2005
2	trametinibIBA 12/2016 - 01/2016
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 12/2016 - 12/2014
2	Interleukin-6 (Interleukin 6)IBA 12/2016 - 01/2016
2	Messenger RNA (mRNA)IBA 12/2016 - 12/2014
2	Ethanol (Ethyl Alcohol)IBA 01/2016 - 07/2012
2	Biomarkers (Surrogate Marker)IBA 12/2015 - 05/2015
2	calpain inhibitorsIBA 06/2015 - 01/2009
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2015 - 01/2007
2	EndotoxinsIBA 02/2015 - 08/2014
2	Interleukin-10 (Interleukin 10)IBA 10/2014 - 05/2010
2	BilirubinIBA 02/2013 - 07/2012
2	CollagenIBA 01/2013 - 10/2012
2	Uncoupling Protein 2IBA 02/2012 - 03/2008
2	Toll-Like Receptor 4IBA 09/2011 - 09/2009
2	Transaminases (Aminotransferases)IBA 09/2011 - 05/2010
2	Clodronic Acid (Clodronate)IBA 09/2011 - 05/2010
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 06/2008 - 01/2007
2	Trichloroethylene (Trichloroethene)IBA 02/2007 - 10/2006
2	StaurosporineIBA 01/2007 - 07/2004
2	Antimycin AIBA 01/2003 - 07/2002
1	RNA (Ribonucleic Acid)IBA 12/2022
1	LipidsIBA 12/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2022
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022
1	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 01/2022
1	LM11A-31IBA 01/2022
1	DAPIIBA 08/2021
1	Retinaldehyde (Retinal)IBA 07/2021

Therapy/Procedure

12	Therapeutics 11/2022 - 01/2007
5	Transplantation 10/2014 - 03/2008
2	Drug Therapy (Chemotherapy) 06/2015 - 01/2007
1	Oral Administration 01/2022